Looking for a weight loss clinic that prescribes GLP-1 medications? Our directory lists 82 verified providers serving Sioux Falls, South Dakota (209,289 residents · 37% adult obesity).
Each clinic below offers GLP-1 weight-loss medications including Ozempic, Wegovy, Mounjaro, and Zepbound. Compare ratings, services, and pricing — then book directly or via our partner directory at GLP1Maps.com.
Sioux Falls, SD
Vital Flow Infusions — Medically supervised semaglutide (from $189/mo) & tirzepatide (from $294/mo). Take-home vials or in-office nurse injections. 15–20% average weight loss. | Sioux Falls, SD
Pricing: $189–$500/mo
Sioux Falls, SD
LIVE Hydration Spa Sioux Falls — 12-week semaglutide & tirzepatide program bundled with B12 and LipoLean injections. Home delivery available. One of SD’s most affordable entry points. | Sioux Falls, SD
Pricing: From $180/mo
Sioux Falls, SD
Refined Aesthetics — Dual telehealth and in-person GLP-1 care. Free initial consultation. Open Mon–Sun for maximum patient convenience. | 4610 S Technopolis Dr, Sioux Falls, SD 57106 | (605) 501-5986
Sioux Falls, SD
The Confidence Collective — Semaglutide 8–10 wk startup $750; tirzepatide 8-wk $850; phentermine + consult $199. Home delivery available. | Sioux Falls, SD
Pricing: $750 (8-wk pkg)
Sioux Falls, SD
Gameday Men’s Health Sioux Falls — Men’s health specialty clinic offering clinician-guided semaglutide and tirzepatide alongside TRT and metabolic programs. | 4908 E Rosa Parks Pl, Sioux Falls, SD 57110 | (605) 600-5454
Sioux Falls, SD
Novo Aesthetics Sioux Falls — Expert-led weight loss program (Rachael Dekker, DNP) with semaglutide & tirzepatide. Monthly check-ins and personalized plans. | 4900 E 57th St Suite B, Sioux Falls, SD 57108 | (605) 359-3877
Sioux Falls, SD
Liv Med Spa — 6- and 12-week programs with full labs (CBC/CMP/TSH/A1C/lipids), GLP-1 supply, monthly follow-ups, and dietician referrals. SD/ND/IA/MN virtual consults. | Sioux Falls, SD
Pricing: From $75/wk
Sioux Falls, SD
Accelerate Wellness — Comprehensive metabolic + hormone assessment with personalized GLP-1 plans. Virtual platform available for ongoing coaching and renewals. | Sioux Falls, SD
Sioux Falls, SD
Radiant Health & Hormone Therapy — Physician-directed GLP-1 programs with free consultation. Telehealth and in-person. Perfect 5-star rated on Google. 5.0H | 4928 E Rosa Parks Pl, Sioux Falls, SD 57110 | (605) 604-0200
Sioux Falls, SD
Kimberly Dewing, PA-C — One of the few SD providers offering liraglutide alongside semaglutide and tirzepatide. Highly reviewed PA-C-led clinic. 5.0H | 5201 E 57th St, Sioux Falls, SD 57108 | (605) 231-9505 This directory is for informational purposes only. Not medical advice. Consult your healthcare provider. — TheGLP1Guide.net 7
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Independent network of GLP-1 resources serving Sioux Falls and patients across the U.S.
Choosing the right GLP-1 provider in Sioux Falls matters. Look for clinics that offer:
GLP-1 receptor agonists work by mimicking a hormone that regulates appetite and blood sugar. The main options:
SD Medicaid covers GLP-1 for diabetes.
For state regulation info, see the South Dakota Medical Board.
Our directory lists 82 verified GLP-1 clinics in the Sioux Falls area, with rankings based on patient reviews, services offered, and verified provider status.
SD Medicaid covers GLP-1 for diabetes.
Following the FDA's April 2026 503B ruling, compounded semaglutide and tirzepatide are no longer available from most U.S. pharmacies. Most clinics now prescribe FDA-approved Ozempic, Wegovy, Mounjaro, or Zepbound.